Chromosomes and Transformation of Lymphocytes in Lymphoproliferative Disorders
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چکیده
منابع مشابه
Chromosomes and transformation of lymphocytes in lymphoproliferative disorders.
In chronic lymphocytic leukaemia the majority of circulating lymphocytes which responded to phytohaemagglutinin in vitro were found to have normal karyotypes. A minor population of cells in patients treated with chemotherapy had an increased number of chromosomal rearrangements as compared with cells from normal controls and untreated patients with chronic lymphocytic leukaemia. Probably bonema...
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The etiologies of anemia in patients with lymphoproliferative disorder (LPD) are diverse. Causes such as acute blood loss or deficiencies in iron or vitamins (folate/B12) are considered in the initial evaluation. In many instances, the anemia can be attributed to marrow infiltration by the LPD. Treatment with chemotherapy can suppress erythropoiesis. Other causes that occur more often with LPD ...
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The immunomodulatory properties of the HLA-G molecule explain its relevance in malignancies. Our investigations in lymphoproliferative disorders show (i) a frequent and variable distribution of alternatively spliced HLA-G mRNA isoforms, (ii) a rare cell surface expression in diffuse large cell lymphomas with HLA class I loss in half of cases, and (iii) an increased serum level of sHLA-G in half...
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Lymphoproliferative disorders including non-Hodgkin lymphomas (NHL) are not uncommon neoplasms in patients infected with the human immunodeficiency virus (HIV). It has been established that HIV-infected individuals are more prone to develop certain lymphoproliferative disorders and lymphomas compared to non-infected individuals. The exact mechanisms underlying these associations is yet to be es...
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ژورنال
عنوان ژورنال: BMJ
سال: 1968
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.4.5625.213